Service models
Rheumatoid arthritis
We provide efficacy evaluation service focused on clinical usefulness of candidate drugs using Type Ⅱ collagen-induced arthritis model and genetically modified mice (knock-in or knock-out of particular genes).
| Model | Evaluation interval | Evaluation items |
|---|---|---|
| DBA/1J Interleukin-1 receptor antagonist knockout (IL-1RaKO) Many genetically modified mice |
Twice a week |
|
Service analysis
Animal model
- Arthritis clinical score evaluation
- Weight changes
- Measurement of antigen-specific IgG in serum
Tissue analysis
- Spleen weight
- Joint inflammation, cartilage damage
- Tissue staining of 4~6 types of inflammatory cytokine*
- Micro CT images of joints
- X-ray images
Cytologic analysis of spleen and lymphatic gland*
- T, B cell subsets and staining*
- Analysis of 4~7 types of cytokine/chemokine* (open to negotiation with researcher)
- Flow cytometry of Th1/2/17, Treg cells (open to negotiation with researcher)
- Analysis of 3 types of genetic markers (open to negotiation with researcher)
