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Systemic Lupus Erythematosus

This disease involves over-activation of B cells that creates auto-antibodies to attack the immune system of the body. We use preclinical animal models (Roquin mutant, NZB/WF1, MRL/lpr).

보유모델 정보
Model	Evaluation interval	Evaluation items
Roquin mutant MRL-lpr	To be decided by researcher	Facial erythema Weight changes in spleen, lymphocyte, kidney and the whole body Kidney and spleen tissue analysis (inflammatory cell infiltration) Histologic analysis of kidney (IgG, C3 deposit) Immune cell of kidney, spleen and blood (T cell, B cell) Serum IgG, anti-ds DNA IgG Analysis of cytokine, chemokine Gene analysis

Animal model

Facial erythema
Survival rate
Weight changes
IgG, anti-ds DNA IgG
Serum anti-Ro, anti-La IgG*
Urine creatinine, albumin
Urine stix

Tissue analysis

Weight changes in spleen, lymphocyte, kidney and the whole body
Tissue analysis of kidney and spleen (H&E & PAS)
Tissue staining of 5 types of inflammatory cytokine*

Cytologic analysis of spleen and blood*

Analysis of immune cell subtypes*
Analysis of 5 types of cytokine/chemokine* (open to negotiation with researcher)
Analysis of 5 types of genetic markers (open to negotiation with researcher)

* Premium Service