Service models
AVATARSS
We have a stable AVATAR system with patient-derived immune cells and skin engrafted. A personalized drug assessment system can be provided as an alternative experimental animal model for clinical trials with patient immune cells by transplanting blood cells derived from patient with systemic sclerosis and skin differentiated from iPSC.
| Model | Evaluation interval | Evaluation items |
|---|---|---|
| NSG mouse |
|
|
Service analysis
Engraftment analysis
- Engraftment analysis by flow cytometry after 3 weeks
- Engraftment analysis by immunochemical staining after 5 weeks
Analysis of pathogenesis in tissues and serum
- Dermal thickness (Hematoxylin & Eosin stain)
- Confirmation of tissue fibrosis (Masson's trichrome stain)
- Immunohistochemical staining (inflammatory cell infiltration and fibrosis analysis)
- Serum analysis
