Service models
Ankylosing spondylitis
We induce autoimmune diseases based on the ankylosing spondylitis-specific SKG mice model, and test efficacy of treatment drugs to analyze their preventive or therapeutic effects.
| Model | Evaluation interval | Evaluation items |
|---|---|---|
| Curdlan ankylosing spondylitis (SKG mice) | Once a week |
|
Service analysis
Animal model
- Arthritis clinical score evaluation
- Uveitis clinical score evaluation
- Weight changes
- Measurement of antigen-specific IgG in serum
- Psoriasis Area and Severity Index (PASI)
Tissue analysis
- Spleen weight
- Joint inflammation, cartilage damage
- Analysis of damaged spinal tissues
- Analysis of damaged intestinal tissues
- Tissue staining of 4~6 types of inflammatory cytokine*
- X-ray image
- Micro-CT image analysis (spinal angle/BMD, TMD/micro-CT score)
Cytologic analysis of spleen and lymphatic gland
- T, B cell subsets and staining
- Analysis of 4~7 types of cytokine/chemokine* (open to negotiation with researcher)
- Flow cytometry of Th1/2/17, Treg cells (open to negotiation with researcher)
- Analysis of 3 types of genetic markers (open to negotiation with researcher)
