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Ankylosing spondylitis

We induce autoimmune diseases based on the ankylosing spondylitis-specific SKG mice model, and test efficacy of treatment drugs to analyze their preventive or therapeutic effects.

보유모델 정보
Model Evaluation interval Evaluation items
Curdlan ankylosing spondylitis (SKG mice) Once a week
  • Joint swelling, changes in weight and spleen weight
  • Histopathological analysis
  • Analysis of serum immunoglobulin
  • Analysis of inflammatory cytokine
  • Analysis of T cell subtype, genes
  • X-ray, micro-CT image analysis

Service analysis

Animal model

  • Arthritis clinical score evaluation
  • Uveitis clinical score evaluation
  • Weight changes
  • Measurement of antigen-specific IgG in serum
  • Psoriasis Area and Severity Index (PASI)

Tissue analysis

  • Spleen weight
  • Joint inflammation, cartilage damage
  • Analysis of damaged spinal tissues
  • Analysis of damaged intestinal tissues
  • Tissue staining of 4~6 types of inflammatory cytokine*
  • X-ray image
  • Micro-CT image analysis (spinal angle/BMD, TMD/micro-CT score)

Cytologic analysis of spleen and lymphatic gland

  • T, B cell subsets and staining
  • Analysis of 4~7 types of cytokine/chemokine* (open to negotiation with researcher)
  • Flow cytometry of Th1/2/17, Treg cells (open to negotiation with researcher)
  • Analysis of 3 types of genetic markers (open to negotiation with researcher)
* Premium Service