Service models
AVATARA/AVATARSS
We use a humanized animal model for rheumatoid arthritis using AVATRA and the humanized animal model for Sjogren’s syndrome using AVATARSS whereby synovial tissues and cells of arthritis patients or salivary gland, blood, salivary gland stem cell of Sjogren’s syndrome patients are implanted into immune-deprived NOD.Cg-Prkdcscid Il2rgtm1wjl/SzJ (NSG) mouse to replicate patients’ abnormal immune system. Based on this model, we provide efficacy evaluation services focused on clinical usefulness.
| Model | Evaluation interval | Evaluation items |
|---|---|---|
| NSG mouse | Daily after implant 3 weeks (transplant cell engraftment) Other analysis (after sacrifice) |
|
Service analysis
AVATARA
- Cytometry of blood cells (CD4, CD8, CD45)
- Cytometry of spleen cells (CD4, CD8, CD45)
- Immunohistochemical staining of implanting patient’s tissues and confocal microscopic analysis (human CD4)
- Immunohistochemical staining of spleen tissues and confocal microscopic analysis
- Serum analysis ( inflammatory cytokines. Etc)
AVATARSS
- Cytometry of blood cells (CD4, CD8, CD45)
- Cytometry of spleen cells (CD4, CD8, CD45)
- Immunohistochemical staining of implanting patient’s tissues and confocal microscopic analysis (human CD4)
- Immunohistochemical staining of spleen tissues and confocal microscopic analysis
- Serum analysis ( inflammatory cytokines. Etc)
