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Service models

Bleomycin–induced Systemic Sclerosis

An animal model of systemic sclerosis using Bleomycin is an animal model that plays an important role in the study of systemic sclerosis by inducing fibrosis of the skin and lungs by administering drugs to the local area. Bleomycin systemic sclerosis animal model can be used to confirm the efficacy of anti-fibrotic drugs through histopathological analysis.

보유모델 정보
Model Evaluation interval Evaluation items
After 3 to 4 weeks of inducing the Bleomycin
  • H&E (skin, lung morphology, dermis thickness)
  • Masson’s Trichrome (skin, lung)
  • Hydroxyproline assay (skin, lung)
  • Immunohistochemistry image analysis (skin)
  • Immunofluorescence image analysis (spleen)

Service analysis

Animal model

  • Weight changes

Tissue analysis

  • H&E and Masson’s Trichrome (skin, lung morphology, dermis thickness)
  • Analysis of 3 species of fiber related factors (IHC)
  • Analysis of 4 species of inflammatory cytokines (IHC, IF)
  • Concentration measurement of collagen (hydroxyproline assay)