Service models
Surgically induced osteoarthritis rabbit and rat model
We provide efficacy evaluation services focused on clinical usefulness of candidate drugs for osteoarthritis, based on research of surgically induced osteoarthritis in rabbits and rats through ACLT (anterior cruciate ligament transection) and MMx (medical meniscectomy).
| Model | Evaluation interval | Evaluation items |
|---|---|---|
| Wistar New Zealand white rabbit |
Once or twice a week |
|
Service analysis
Animal model
- Weight changes
- Level of pain
Tissue analysis
- Analysis of joints, inflammation, cartilage damage (H&E stain, Saframin O stain)
- Tissue staining of 4~6 types of inflammatory cytokine (IHC added)
Imaging analysis
- Extent of damage to the shinbone and thighbone (Micro-CT/MRI)
