Service models
Osteoarthritis
Injection of monosodium Iodoacetate (MIA) into a mouse’s glenoid cavity quickly causes cartilage damage, and it is an effective animal model that enables efficacy evaluation within four weeks. Based on this, we provide efficacy evaluation services focused on clinical usefulness of candidate drugs.
| Model | Evaluation interval | Evaluation items |
|---|---|---|
| Wistar rats | Once or twice a week |
|
Service analysis
- Dynamic planter aesthesiometer; paw withdrawal latency (PLW), paw withdrawal threshold (PWT)
- Incapacitance meter: weight bearing
- Histological analysis
(H&E, Safranin O, India ink stain : OARSI, Total Mankin score, India ink score analysis - Immunohistochemistry IL-1ß, IL-б, MMP1, 3, 13 et al. (Customization available)
- Micro-CT (bone volume, bone surface analysis), MRI*
- Anabolic, catabolic market analysis available for drug treatment that uses osteoarthritis patients’ chondrocyte*
