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Service models

Experimental autoimmune encephalomyelitis (EAE)

C57BL/6 mice are widely used in the EAE model as they show a chronic and more gradual progress in disease compared to PL/J or B10.PL that show more acute and self-restrictive progress. Using this model, we provide efficacy evaluation services focused on clinical usefulness of candidate drugs targeting multiple sclerosis.

보유모델 정보
Model Evaluation interval Evaluation items
C57BL/6 mice
Wistar rats
  • EAE clinical score evaluation/ weight changes
  • White matter inflammation and demyelination
  • Axon damage/inflammatory cell infiltration
  • Serum IgG, antigen-specific IgG, autoantibody
  • Changes in inflammatory cells, cytokine and gene expression in response to drugs

Service analysis

Animal model

  • EAE clinical score evaluation
  • Weight changes
  • Serum IgG, antigen-specific IgG, AQP4 autoantibody*

Brain and spinal cord tissues

  • White matter inflammation and demyelination
  • Axon damage (SMI312 IHC)
  • T2 & T1-enhanced lesion*
  • IHC test for CD3/19/68 in lesion*
  • Detection of IgG/C9neo in lesion*
  • GFAP stain for astrocyte damage*

Cytologic analysis of spleen and lymphatic gland

  • Proliferation and death of target cells
  • Analysis of 5 types of cytokine/chemokine* (open to negotiation with researcher)
  • Cytometry (Th1/2/17, Treg)
  • Analysis of 5 types of genetic markers (open to negotiation with researcher)

Immune cells derived from multiple sclerosis patients*

  • Open to negotiation with researcher
* Premium Service