Service models
Obese rheumatoid arthritis
We provide efficacy evaluation services for candidate drugs targeting inflammation and abnormal metabolism using an animal model of obese rheumatoid arthritis caused by high fat diet (HFD)
| Model | Evaluation interval | Evaluation items |
|---|---|---|
| DBA/1J C57Bl/6 Genetically modified mice |
Twice a week |
|
Service analysis
Animal model
- Arthritis clinical score evaluation
- Weight changes
- Measurement of antigen-specific IgG in serum
- Serum glucose, LDL-cholesterol, total cholesterol, triglyceride
Tissue analysis
- Spleen weight
- Joint inflammation, cartilage damage
- Tissue staining of 4~6 types of inflammatory cytokine*
- Micro CT images of joints
- X-ray images
- In vivo imaging micro-CT (micro-computed tomography)
Cytologic analysis of spleen and lymphatic gland
- T, B cell subsets and staining
- Analysis of 4~7 types of cytokine/chemokine*(open to negotiation with researcher)
- Flow cytometry of Th1/2/17, Treg cells (open to negotiation with researcher)
- Analysis of 3 types of genetic markers (open to negotiation with researcher)
