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Rheumatoid Arthritis model with Cynomolgus Monkey

We use an animal model that examines cynomolgus monkeys with typeⅡ collagen-induced arthritis, and provide efficacy evaluation services focused on clinical usefulness of drugs targeting rheumatoid arthritis.

동물모델 정보
Model	Evaluation interval	Evaluation items
Cynomolgus Monkey	Once a week	Joint swelling, changes in spleen weight, body weight Histological analysis Serum immune globulin (IgG, M) Inflammatory cytokine (IL-6, TNF-α) Blood cell, biochemical analysis Imaging, X-ray, CT

Service analysis

Animal model

Arthritis clinical score evaluation
Weight changes
Changes in remaining feed

Blood and urine analysis

Serum IgG, M*
C-relative protein
HP, LP/creatine*

Tissue analysis

Weight changes in spleen
Joint inflammation, cartilage damage
Tissue staining of 3 types of inflammatory cytokine
X-ray, micro CT*

Cytologic analysis of spleen and lymphatic gland

Fluorescent staining of T cells and B cells*
Analysis of 3 types of cytokine (open to negotiation with researcher)*
Cytometry (Th1/2/17, Treg; open to negotiation with researcher)*

* Premium Service