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Rheumatoid Arthritis model with Cynomolgus Monkey

We use an animal model that examines cynomolgus monkeys with typeⅡ collagen-induced arthritis, and provide efficacy evaluation services focused on clinical usefulness of drugs targeting rheumatoid arthritis.

동물모델 정보
Model Evaluation interval Evaluation items
Cynomolgus Monkey Once a week
  • Joint swelling, changes in spleen weight, body weight
  • Histological analysis
  • Serum immune globulin (IgG, M)
  • Inflammatory cytokine (IL-6, TNF-α)
  • Blood cell, biochemical analysis
  • Imaging, X-ray, CT

Service analysis

Animal model

  • Arthritis clinical score evaluation
  • Weight changes
  • Changes in remaining feed

Blood and urine analysis

  • Serum IgG, M*
  • C-relative protein
  • HP, LP/creatine*

Tissue analysis

  • Weight changes in spleen
  • Joint inflammation, cartilage damage
  • Tissue staining of 3 types of inflammatory cytokine
  • X-ray, micro CT*

Cytologic analysis of spleen and lymphatic gland

  • Fluorescent staining of T cells and B cells*
  • Analysis of 3 types of cytokine (open to negotiation with researcher)*
  • Cytometry (Th1/2/17, Treg; open to negotiation with researcher)*
* Premium Service